3P-41 PDF
Insulinおよびinsulin chain Bイオンの立体構造とプロトン移動反応に関する研究
Peptide or protein involved in biomolecules function different types from the structure of the original materials. The purpose of this research is to study the three-dimensional structures of the biomolecular ions in reactions with gaseous molecules. We studied the tertiary structures of insulin (Ins) ions and insulin chain B (Ins B) ions in the gas phase. We used a tandem mass spectrometer with electrospray ionization (ESI). We changed temperature and reaction time of the collision cell. The target molecules used were 1, 4-butanediamine (Bda). By time-dependent measurement, we kept constant in temperature and changed reaction time from 1 to 87ms. By temperature-dependent measurement, we kept constant in reaction time and changed temperature of the gas cell from 289 to 452K.