The 51st Annual Conference on Mass Spectrometry (2003), Tsukuba, Japan

  1st Day Wednesday, May 14, 2003 Program

 Auditorium    "Symposium Session"
  Symposium 1 "Drug discovery & MS"
  ( 9:30-11:50 )Chairpersons: Yutaka Hashimoto, Takeshi Kinoshita
1-S-01Natural products and mass spectrometry
(Fujisawa)
Nobuharu Shigematsu
1-S-02Role of Mass Spectrometry for Drug Metabolism and Pharmacokinetics Research
(Discovery Metabolism Research, Yamanouchi Pharmaceutical Co., Ltd.)
Hiroya Miura
1-S-03Genome based drug discovery in Eisai
(Eisai)
Takeshi Nagasu
1-S-04The role of LC/MS system in high throughput chemistry (HTC)
(Research Division, Glaxo Smith Kline K.K.)
Ichiro Morimoto
1-S-05Difference in drug discovery strategy between Japanese and U.S. pharmaceutical industries
(Banyu Tsukuba Research Institute)
Susumu Nishimura

  Business meeting of MSSJ
  ( 12:00-12:50 )

  Invited lecture 1
  ( 15:00-15:45 )Chairperson: Zenzaburo Tozuka
1-T-01New Strategies for Automated LC/MS and Data Processing of Small and Large Molecules in Life Sciences Research
(1Novatia, LLC, Princeton, 2Michrom BioResources, Auburn)
oMark E. Hail1, Jeffrey L. Whitney1, David J. Detlefsen1, Kerry D.Nugent2

  Invited lecture 2
  ( 16:00-16:45 )Chairperson: Takemichi Nakamura
1-T-02Mass Spectrometric Strategies for Screening Natural Toxins in Tropical Venomous Organisms
(Laboratory of Structural Biology and Zoochemistry-CEIS/Dept. Biology, Institute of Biosciences, Sao Paulo State University)
oPalma, M. S., Mendes, M. A., Marques, M. R., Souza, B. M., Cesar, L. M. M., Santos, L. D., Santos, K. S.

  Invited lecture 3
  ( 17:00-17:45 )Chairperson: Junichi Goto
1-T-03Mass spectrometry-based approaches for analysis of oxidative damage to DNA and proteins
(Center for Cancer Pharmacology and Genomics Institute Proteomics Facility, University of Pennsylvania)
oIan A. Blair


 Conference room 1
  Oral presentations "Molecular association, Cluster, Data base"
  ( 9:30-10:30 )Chairperson: Toshihide Nishimura
1-O1-01Structure and Energy Correlation of Hydrogen-bonded Complexes of Phenylacetylides and Methanol
(Institute for Material Chemistry and Engineering, Kyushu Univ.)
oM. Mishima, Mio Matsuoka
1-O1-02Formations and Structural Analysis of Coordination Products, Ni(II) and Zn(II) with o-Phenanthroline or 2,2′-Bipyridine by Spray Ionization
(Grad. School of Eng. Osaka Univ.)
oMasana Arimura, Gen-etsu Matsubayashi
1-O1-03Dissociation processes of MgCH3I+ cluster ion from excited electronic states
(Department of Chemistry, Graduate School of Science, Tohoku Univ.)
oAri Furuya, Hironori Tsunoyama, Fuminori Misaizu, Koichi Ohno
  ( 10:30-11:10 )Chairperson: Kenzo Hiraoka
1-O1-04Study of intracluster anionic polymerization reactions induced by electron transfer from an alkali metal atom
(Department of Chemistry, Graduate School of Science, Tohoku Univ.)
oFuminori Misaizu, Keijiro Ohshimo, Hironori Tsunoyama, Ari Furuya, Koichi Ohno
1-O1-05Isomeric structures of gas-phase C2H5+(OCS)n
(1Clean Energy Res. Center, Yamanashi Univ.,  2MEIKO Co., Ltd., 3Department of Chemistry, Nara Univ. of Education)
oK. Fujita1, F. Nakagawa1, M. Ishida1, K. Akiyama1, K. Hiizumi2, K. Hiraoka1, S. Yamabe3
  ( 11:10-11:50 )Chairperson: Ryuichi Arakawa
1-O1-06Clusters of alcoholic solutions studied by liquid ionization mass spectrometry-methanol and ethanol
(1Yokohama National Univ., 2Toyaku Univ., 3Hosei Univ.)
oMasahiko Tsuchiya1, Yasuo Shida2, Kenichi Kobayashi3, Osamu Taniguchi3, Shouichi Okouchi3
1-O1-07Mass Spectral Data Base Actively Utilizing the Internet Facilities (III) Present Situation of High Speed Communications on Web Networks
(1Japan ASTEC, 2INJ)
H. Rokusha, oKogure Maeda2

  Luncheon seminer
  ( 12:00-13:30 )Amersham Biosciences

  Oral presentations "Proteome Protein"
  ( 15:00-15:40 )Chairperson: Takemichi Nakamura
1-O1-08Use and problems of 2D-PAGE based proteomics in drug discovery research
(1Analysis Research, 2Genomics Research, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.)
oMasashi Hiramoto1, Hiroyuki Yokota2
1-O1-09Problems and future aspects on isotope-coded affinity tag (ICAT) method
(Analysis Research, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.)
Masashi Hiramoto
  ( 15:40-16:20 )Chairperson: Takao Kawakami
1-O1-10Proteomic analysis of brain proteins related to the ischemic neuronal apoptosis
(1Tumor Gen. & Biol., Kumamoto Univ. Sch. of Med., 2SRL, Inc., 3Molecular Biol. Tokyo Metro. Inst. of Gerontol., 4Biochem. Sch. of Agric. Kyushu Tokai Univ., 5Proteomics Research Lab., 6Neurol., Neurological Inst., Grad. Sch. of Med. Sci., Kyushu Univ.)
oNorie Araki1, Siriporn Patrakitkomjorn1, L. Feng1, T. Ozawa1, Katsumi Kawano2, Toshifusa Toda3, Tomohiro Araki4, A. Tsugita5, J. Kira6, Hideyuki Saya1
1-O1-11Topological analysis of cytochrome P450 17a which reconstituted into liposomes
(1Graduate School of Science, 2Faculty of Integrated Arts and Sciences, Hiroshima Univ.)
Hajime Mizuno1, Hiroshi Kaneko2, Qhunsuke Izumi1, Takeshi Yamasaki2, Toshifumi Hirata1, Sirou Kominami2
  ( 16:20-17:00 )Chairperson: Naoyuki Yamada
1-O1-12Analysis for phosphorylated proteins in the activated human T-cell clone using high-resolution mass spectrometer
(1Dept. Immunogenetics, Kumamoto Univ. Grad. Sch. Med. Sci., 2Dept. Oncology, Kumamoto Univ. Sch. Med.)
oAtsushi Irie1, Kumiko Takeshita1, Hirotake Tsukamoto1, Norie Araki2, Yasuharu Nishimura1
1-O1-13Rapid development of purification process using RC-SELDI-MS
(Ciphergen Biosystems K. K., Yokohama Lab.)
oM. Shiwa, R. Wakatabe

 Conference room 2
  Tropo-mass spectrometry workshop
  ( 9:30-12:00 )

  Luncheon seminer
  ( 12:00-13:30 )Waters & JASCO

  Tropo-mass spectrometry workshop
  ( 15:00-17:20 )


 Foyer & Poster room
  Poster presentations
  ( 13:30-15:00 )Chairperson: Toshihide Nishimura
1-P-01Splitless low-flow LC/MS for proteins and peptides
(Graduate School of Integrated Science, Yokohama City Univ.)
oYoshiyuki Itoh, Yoshifumi Nishimura, Satoko Akashi
1-P-02A robust nano ESI technique for protein analysis using tapered 30 μm internal diameter stainless-steel needle as an ESI emitter
(Institute of Life Sciences, Ajinomoto Co., Inc.)
oMasana Arimura, Gen-etsu Matsubayashi
1-P-03Peptide sequence information by LC-Frit-FAB/MS
(Center for Analytical Chemistry and Science, Inc., Yokohama Laboratory)
oNaoko Takeda, M. Ozawa
1-P-04Peptide mass fingerprinting by combination of gas-phase edman degradation and MALDI-MS
(1 Institute for Protein Research, Osaka Univ., 2 Asahi Techneion Co., Ltd.)
Yoshinori Tamura2, Toshifumi Takao1
1-P-05Nobel sequence analysis of peptide in MALDI TOF-MS-PSD method by the modification with fluorescent reagent
(1 National Institute of Advanced Industrial Science and Technology, 2 Dept. of Chem., Schl. Sci., The Univ. of Tokyo)
oMasatoshi Nakagawa1, Tohru Yamagaki2, Hiroshi Nakanishi1
1-P-06Rapid Analysis of Digested Proteins by Atmospheric PressureMALDI/Ion Trap Mass Spectrometry
(Yokogawa Analytical Systems, Inc.)
oHirokazu Sawada, Naoto Shimizu, Hiroki Kumagai
1-P-07A protein processing method for direct proteomics
(Biomolecular Characterization Division, RIKEN)
oHiromi Miura, Koji Takio, Hiroshi Nakayama
1-P-08Proteome analysis of Escherichia coli by SDSPAGE and 2-Dimensional LC/MS/MS
(National Institute of Technology and Evaluation)
oHanako Ishikawa, Miyako Mise, Keiko Nishijima, Kazumi Sasaki
1-P-09Mass-spectrometric tags for quantitation of expression proteome: Application to disease model animals
(Clinical Proteome Center, Tokyo Medical Univ.)
oTakao Kawakami, Naoki Nakamura, Hisae Anyoji, Atsushi Ogiwara, Toshihide Nishimura
1-P-10Proteomics analysis of proteinprotein interaction caused by EGF using LC-MS/MS for a computational simulation of signal transduction
(RIKEN Genomic Science Center (GSC) Bioinformatics Group)
oKazumi Matsumura, Aki Hasegawa, Xiaomei Yu, Mariko Hatakeyama, Fumikazu Konishi, Akihiko Konagaya
1-P-11Quantitative Aspects in Direct Characterization of Digested Protein Complex: An Approach Based on High-Accuracy Mass Chromatographic Analysis with FT ICR MS
(1 RIKEN Biomolecular Characterization, 2 RIKEN Harima Institute)
oTakemichi Nakamura1, Naoshi Dohmae1, Koji Takio2
1-P-12Proteome Analysis of PSD Fraction Using Multi-Dimensional Separation
(1 Can Research, 2 Laboratory of Seeds Finding Technology, Eisai Co., Ltd.)
oKeiko Sato1, Yoshiya Oda2, Hiroyuki Katayama2, Tsuyoshi Tabata2, Masakazu Takeuchi1, Maki Tawarada1, Takeshi Nagasu2
1-P-13Optimization of in-gel digestion system in combination with thin gel separation and negative staining in 96-well plate format
(Laboratory of Seeds Finding Technology, Eisai Co., Ltd.)
oHiroyuki Katayama, Yoshiya Oda, Takeshi Nagasu
1-P-14Multiple Large Gel Two-dimensional Electrophoresis for Proteomics
(1 Division of Signal Transduction, Nara Institute of Science and Technology, 2 Recognition and Formation, PRESTO, JST)
oKazuhiro Katsuta1, Tatsuya Mori1, Tomoko Ueda1, Naoyuki Inagaki2
1-P-15Profiling of Basic Proteins Expression Using 2-DE
(1 Division of Signal Transduction, Nara Institute of Science and Technology, 2 Recognition and Formation, PREST, JST)
oTatsuya Mori1, kazuhiro Katsuta1, Tomoko Ueda1, Naoyuki Inagaki2
1-P-16Examination of various gel stain method for in-gel digestion
(1 Division of Signal Transduction, NAIST, 2 Recognition & Formation, PRESTO, JST)
oMichinori Toriyama1, Eiko Nomura1, Naoyuki Inagaki1, 2
1-P-17Improvement of in-gel protein digestion for proteomics
(1 Division of Signal Transduction, NAIST, 2 Recognition & Formation, PRESTO, JST)
oEiko Nomura1, Michinori Toriyama1, Naoyuki Inagaki1, 2
1-P-18Study on Proteomics for Human Plasma (1) In-solution digestion
(1 Dept. Human Genetics, Mount Sinai School of Medicine, 2 Clinical Proteome Center, Tokyo Medical Univ.)
Kiyonaga Fujii1, 2, Toshihide Nishimura2, Rong Wang1
1-P-19SYPRO Ruby stain frequently induces oxidization of methionine residue which reduces the efficiency of the protein identification with the MASCOT search
(1 Developments of Hair Regeneration Therapy and Functional Proteomics, Innovation Plaza Hiroshima, JST, 2 TOWA KAGAKU Co., Ltd., 3 Prophoenix Co., Ltd., 4 Cooperative Link of Unique Science and Technology for Economy Revitalization (CLUSTER) Hiroshima Prefectural Institute of Industrial Science and Technology, 5 Developmental Biology Laboratory, Department of Biological Science, Graduate School of Science, Hiroshima University)
oYoshiko Takeda1, Akira Yamagata1, 2, 3, Yuka Myoken1, Mutsumi Inamatsu1, Ken Oofusa1, 2, 3, Katsutoshi Yoshizato1, 4, 5
1-P-20The influence of water quality for proteome analysis by LC/MS
(Nihon Millipore K. K.)
Naoe Ishii
1-P-21ESIMS of Polysaccharides: Inclusion of Permethylated Inulin with Alkali Metal Ions
(1 ISIR, Osaka Univ., 2 Osaka Institute of Technology)
oYoshio Takai1, Gakuto Goshima2, Jyuichi Tanaka2, Masami Sawada1
1-P-22Hostguest chiral recognition system in nano-ESI mass spectrometry
(1 ISIR, Osaka Univ., 2 Kansai Univ., 3 Osaka Municipal Techn. Res. Inst., 4 Graduate School of Engineering Sci., Osaka Univ.)
oHitoshi Yamada1, Muneyoshi Yoshikawa2, Motohiro Shizuma3, Kazuo Fukuda4, Yoshio Takai1, Ryuichi Arakawa2, Masami Sawada1
1-P-23New hostmetalguest chiral recognition system to determine the enantiomeric excess of the guests using ESIMS/MS
(1 Osaka Municipal Techn. Res. Inst., 2 Osaka Inst. Techn., ISIR, 3 Osaka Univ.)
oMotohiro Shizuma1, Masamichi Muranaka2, Hitoshi Yamada3, Yoshio Takai3, Jyuichi Tanaka3, Masami Sawada2
1-P-24Chiral recognition of new acyclic hosts containing mannofuranose moieties
(1 Osaka Municipal Techn. Res. Inst., 2 ISIR, Osaka Univ.)
oMotohiro Shizuma1, Hitoshi Yamada2, Yoshio Takai2, Tokuji Takeda1, Masami Sawada2
1-P-25On-line ESI-MS of the reaction products of 1,3-butadiene diepoxide in supercritical fluids
(Faculty of Engineering, Kansai Univ.)
oRyuichi Arakawa, Tsuyoshi Hukuo
1-P-26Detection of Peroxides Using Triphenyl Phosphine Reagent by EI Mass Spectrometry
(Kanagawa Univ.)
oY. Mochida, G. Arai, S. Nakamura
1-P-27Synthesis of Heterofullerene and Its Characterization with a Double Focusing Tandem Mass Spectrometry
(1 National Institute of Advanced Industrial Science and Technology, 2 Japan Fine Ceramics Center)
oTakako Nakamura1, Keiichiro Ishikawa1, Akiko Goto2, Masatou Ishihara1, Tsuguyori Ohana1, Yoshinori Koga1
1-P-28Mass spectromety of dyes by Frit-FAB
(CACs)
oKeishi Oba
1-P-29Mass Spectrometry of pigments and Polymers by Desorption Chemical Ionization
(CACs)
oShuji Kagawa
1-P-30Analysis of Additives in Lithium Ion Battery Electrolyte by MALDI-TOF MS
(1 CACs, Inc., 2 Mitsubishi Chemical Corporation)
oTakuya Hatozaki1, Naohide Takesue1, Kenji Shiduka2, Kunihisa Shima2, Makoto Ue2
1-P-31Interlaboratory Comparison of Polymer Molecular Mass Distribution by MALDI-TOFMS
(1 National Institute of Advanced Industrial Science and Technology, 2 TORAY Research Center Inc., 3 SHIMADZU Corporation, 4 Federal Institute for Materials Research and Testing (BAM))
Shinichi Kinugasa1, Hisashi Togashi1, Ritsuko Nagahata1, Shigetomo Matsuyama1, Hiroaki Sato1, Kayori Shimada1, N. Sato2, S. Kawabata3, Steffen M. Weidner4
1-P-32Conformational effects on molecular mass distributions of synthetic polymers measured by MALDI-TOFMS
(1 National Institute of Advanced Industrial Science and Technology, 2 SHIMADZU Corporation)
oKayori Shimada1, Marina A. Lusenkova1, Keisuke Sato1, Shigetomo Matsuyama1, Ritsuko Nagahata1, Shinichi Kinugasa1, Shin-ichirou Kawabata2
1-P-33UV-MALDI-TOF-MS Analysis of Poly-(silsesquioxane)s Derived from the HydroliticCondensationofOrganotrialkoxy-silanes Containing Hydroxyl Groups
(1 Cihidecar-Conicet, 2 Intema, 3 College of Agriculture, Ehime Univ.)
Rosa Erra-Balsells1, Ignacio E. dell'Erba2, Diana P. Fasce2, Roberto J. J. Williams2, Yuko Fukuyama3, Yasuto Sato3, Hiroshi Nonami3
1-P-34Mass Spectrometric Analysis of Synthetic Polymers by Desorption/Ionization on Porous Silicon
(Fac. of Engineering, Kansai Univ.)
oYukiyasu Shimomae, Kazuma Ohara, Ryuichi Arakawa
1-P-35New matrix for MALDI-TOFMS and application to synthetic polymer
(Sumitomo Chemical Co., Ltd.)
oHiroshi Takigawa, Hideaki Nakajima, Akihiko Okada, Toshio Sasaki
1-P-36Direct characterization of polymeric hindered amine light stabilizer in polypropylene by reactive thermal desorptiongas chromatography and matrix assisted laser desorption ionization mass sepctrometry using solid sampling technique
(1 Graduate School of Engineering, Nagoya Univ., 2 Research Center for Advanced Energy Conversion, Nagoya Univ., 3 Aichi Institute of Technology)
oHajime Ohtani1, Yoshihiko Taguchi1, Yasuyuki Ishida2, Shin Tsuge3
1-P-37Fundamentals for Characterization of Synthetic Polymers by SEC/MALDI-MS
(1 Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), 2 Graduate School of Engineering, Nagoya Univ.)
oHiroaki Sato1, Hiroaki Tao1, Hajime Ohtani2
1-P-38Elimination processes of guest molecules from the inclusion complexes of butanols + deoxycholic acid
(Depaertment of Chemistry, Kinki Univ.)
oTakayoshi Kimura, Kimihide Tsujimoto, Tadasi Kamiyama
1-P-39Thermal decomposition process of fire-retardant cables
(Nohmi Bosai Ltd., Research Laboratory)
oKatsuhiro Suzuki, Maya Maekawa, Takashi Nohmi
1-P-40Oligosaccharides: Universal Calibrants for both Positive and Negative Mode of Electrospray Ionization Mass Spectrometry
(Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.)
oKazuko Yamashita, M. Okamoto, K. Nakai
1-P-41Development of Cold-Spray Ion Source for LC-TOFMS
(1 JEOL Ltd., 2 Chemical Analysis Center, Chiba Univ.)
oKiyotaka Konuma1, Tetsuichiro Morita1, Junichi Osuga1, Kazuko Tanaka1, Yutaka Takahashi1, Tatsuji Kobayashi1, Jun Tamura1, Yoshihisa Ueda1, Kentaro Yamaguchi2
1-P-42Development and application of new ion sources for LC-TOFMS
(JEOL Application Research Center)
oKazuko Tanaka, Junichi Osuga, Kiyotaka Konuma, Yoshihisa Ueda, Tetsuichiro Morita
1-P-43Development and Applications of CE-MS Interface for LC-TOFMS
(JEOL Ltd.)
oYutaka Takahashi, Tetsuichiro Morita, Kenji Nagatomo, Tatsuji Kobayashi, Yasunori Nishimura, Jun Tamura
1-P-44Measurement and evaluation of spatial distribution of droplet size and flow velocity in the ESI spray by PDPA (Phase Doppler Particle Analyzer)
(1 Technology Research Lab., 2 Production Design Technology Center, 3 Analytical & Measuring Instruments Division, 4 Shimadzu Corporation; Department of Mechanical and Systems Engineering, Kansai Univ.)
oSadao Takeuchi1, Fujio Inoue2, Mitsuaki Fukuda3, Takahiro Harada1, Shigeki Hayashi1, Tsutomu Tajikawa4, Atsushi Sakurai4, Kenkichi Ohba4
1-P-45Development of a novel nanoflow interface in nLC/MS
(Central Research Laboratory, Hitachi Ltd.)
Atsumu Hirabayashi
1-P-46Development of IR-FEL/UV MALDI-TOFMS
(nstitute of Free Electron Laser, Graduate School of Engineering, Osaka Univ.)
oYasuhide Naito, Katsunori Ishii, Sachiko Suzuki, Kunio Awazu
1-P-47Development of a High Sensitivity Gas Chromatograph Mass Spectrograph with a CCD Array Detector
(1 Osaka Univ., 2 CREST)
oMichisato Toyoda1, Hiroki Sakae2, Toshio Ichihara1, Morio Ishihara1, Itsuo Katakuse1
1-P-48Performance test of a double focusing mass spectrograph for lunar and planetary exploration
(1 Faculty of Science, Osaka Univ., 2 National Space Development Agency of Japan)
oKouhei Ueda1, Masaru Nishiguchi1, Michisato Toyoda1, Morio Ishihara1, Makiko Ohtake2, Takamitsu Sugihara2, Itsuo Katakuse1
1-P-49Development of TOF-MS for space dust measurement by using hypervelocity microparticles
(1 RCNST, Univ. Tokyo, IAA, 2 Fac. Sci., Univ. Tokyo, 3 Dokkyo Med. Univ., 4 Tokyo Univ. Fishery)
oHiroshi Shibata1, Y. Hamabe1, S. Sasaki2, T. Kawamura3, K. Nogami3, H. Ohashi4, Hypervelocity Microparticle Impact Experimental Group.
1-P-50Development of a reflectron time-of-flight mass spectrometer to attain a higher mass resolution and a wider mass range
(National Institute of Advanced Industrial Science and Technology)
oNaoaki Saito, Eiichi Takahashi, Eisuke Miura, Kazuyoshi Koyama, Mitsumori Tanimoto
1-P-51Performance evaluation of multi turn time of flight mass spectrometer 'MULTUM Linear plus' --measurement of organic compound--
(Osaka Univ.)
oTakuro Hagiwara, Daisuke Okumura, Michisato Toyoda, Morio Ishihara, Itsuo Katakuse
1-P-52Measurements of high mass ions produced by MALDI using Multi-Turn TOF mass spectrometer 'MULTUM II'
(Department of Physics, Graduate School of Science, Osaka Univ.)
oDaiskue Okumura, Michiato Toyoda, Morio Ishihara, Itsuo Katakuse
1-P-53Simulation of ion injection into a RF ion trap
(Faculty of Science, Osaka Univ)
Kenji Sasaki, oMorio Ishihara, Michisato Toyoda, Kosuke Kumondai, Itsuo Katakuse