Program

Poster Presentations

Day 3, June 12（Fri.）　　Room P (5F 501+502)

3P-44

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Investigation on the Ionization Conditions for Mass Spectrometry Imaging of a Boron Agent PBC-IP for Boron Neutron Capture Therapy

(¹UOsaka, ²Science Tokyo)
^oRena Yamashita¹, Hiroyuki Nakamura², Hisanao Hazama¹

This study investigated the optimal ionization conditions for PBC-IP, a novel boron cluster agent for boron neutron capture therapy (BNCT), to enable high-resolution mass spectrometry imaging. Using a MALDI-TOF mass spectrometer, the effects of different matrices (CHCA, DHB, and 1,5-DAN) and ion modes on signal intensity and reproducibility were evaluated. Results showed that ion signal peaks for PBC-IP were detected only with CHCA in both positive and negative modes, and with DHB in negative mode. While the largest peak areas were obtained using CHCA in negative mode, this condition exhibited a relatively large relative standard deviation (RSD). Conversely, using DHB in negative mode yielded smaller peak areas—less than one-fourth of those with CHCA—but provided a comparatively small RSD of approximately 30%. These findings indicate that ionization behavior is highly dependent on the matrix and ion mode, suggesting that while CHCA is superior for sensitivity, DHB may be more suitable for achieving stable and reproducible measurements.

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