Program

Poster Presentations

Day 3, June 12（Fri.）　　Room P (5F 501+502)

3P-27

PDF

Development of a Long-Term Stress Assessment Approach Based on Attenuation Correction of Glucocorticoids in Hair

(¹Toyama Pref. Univ., ²Shinshu Univ., ³Kanazawa Univ.)
^oKokoro Okawa¹, Riko Takata^1,2, Shigehiro Karashima³, Issey Osaka¹

Steroid hormones are essential for physiological homeostasis, and cortisol is central to the stress response. Long-term monitoring is desirable. However, serial daily sampling at fixed times is impractical and influenced by circadian variation. Hair grows approximately 1.0 cm per month and incorporates endogenous metabolites, enabling retrospective assessment. Hair strands were segmented at 0.5 cm intervals and analyzed for cortisol and cortisone using LC/MS. Both samples showed decreasing concentrations from proximal to distal segments. Cortisone levels in hair were positively correlated with saliva concentrations, supporting its potential as a biomarker of long-term glucocorticoid exposure.

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