Program

Poster Presentations

Day 3, June 12（Fri.）　　Room P (5F 501+502)

3P-25

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ICP-MS Determination of Toxic Elements via an Aerogel-Packed 3D-Printed Microfluidic Microextraction Device

(¹Kaohsiung Medical University, ²University of Maryland School of Medicine)
Kainat Ishaq¹, Emmanuvel Arputharaj², ^oYeou-Lih Huang¹

Sensitive determination of trace toxic elements in complex biological matrices remains challenging due to severe matrix interference and the extremely low abundance of target ions. Here, we present a sustainable microfluidic microextraction strategy coupled with inductively coupled plasma mass spectrometry (ICP-MS) for efficient determination of toxic elements in serum samples. The system utilizes a reusable 3D-printed microfluidic device packed with a bio-derived aerogel composed of self-assembled amyloid-like lysozyme fibrillar aggregates integrated with graphitic carbon nitride nanosheets and polyethyleneimine. This hierarchical aerogel provides a porous network rich in multifunctional binding sites, enabling rapid and selective capture of metal ions.
Coupled with ICP-MS, the platform achieves effective enrichment and matrix removal prior to detection. The method shows excellent analytical performance with limits of detection of 0.2 μg L⁻¹ for Cr, 0.4 μg L⁻¹ for Se, and 1.1 μg L⁻¹ for Ag, with good precision (RSD 2.1–4.6%). Spike-recovery experiments in serum yielded recoveries of 85–102%. The aerogel-packed device maintained stable performance over at least seven adsorption–desorption cycles. This approach demonstrates the potential of repurposed amyloid-like biomaterials as sustainable sorbents for high-sensitivity elemental analysis.

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