Program

Poster Presentations

Day 3, June 12（Fri.）　　Room P (5F 501+502)

3P-06

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Identification and Molecular Characterization of Fibrinogen Gamma Chain Associated with Early-Stage Pancreatic Cancer

(¹Yokohama City Univ., ²Yokohama City Univ.)
Takeshi Mukai¹, ^oDaisuke Takakura¹, Kensuke Kubota², Noritoshi Kobayashi², Yasushi Ichikawa², Nana Kawasaki¹

Pancreatic cancer is a lethal disease that requires effective biomarkers for early detection. Using mass-spectrometry–based glycoproteomics, serum glycopeptides from patients with pancreatic cancer were profiled. LC/MS/MS identified a fibrinogen γ chain (FGG)–derived glycopeptide that was consistently elevated, particularly in early-stage disease. Receiver operating characteristic curve analysis demonstrated superior diagnostic performance compared with CA19-9. To address the structural context beyond glycopeptide-level identification, the molecular characteristics of FGG were examined. Additional analyses suggested that oligomeric FGG structures are mediated by isopeptide linkages. Public database analysis showed elevated FGG mRNA expression in tumor tissues, and western blotting of pancreatic cancer cell lines revealed high-molecular-weight FGG bands, corresponding to oligomeric forms. These results highlight the importance of the integrated identification and molecular characterization of early-pancreatic-cancer–associated FGG.

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