Symposium Sessions
Day 3, June 12（Fri.） 15:10-15:30 Room B (4F 411+412)
- 3B-S2-1510
Breath-based disease monitoring technology targeting volatile metabolites
(Kyoto Univ.)
oYuta Matsuoka
Human breath volatile metabolites are emerging as promising non-invasive biomarkers. However, for most compounds, biosynthetic origins remain unidentified and their links to individual health are poorly understood, resulting in very limited clinical implementation of breath biomarkers. To address these gaps, we employ multi-scale approaches spanning molecules, cells, animals, and humans to develop breath markers that respond selectively to defined metabolic reactions, aiming to establish a platform for breath-based monitoring of disease metabolism. Ferroptosis is an iron-dependent, lipid peroxidation–driven process that amplifies tissue inflammation and contributes to diverse age-related diseases. Notably, a subset of oxidized lipids generated during ferroptosis is volatile and can be exhaled. Building on this concept, we have developed and advanced toward clinical translation a non-invasive method to detect deep-tissue ferroptosis using exhaled volatile oxidized lipids as biomarkers. In this presentation, we will focus on the development of ferroptosis-associated breath markers and discuss broader strategies and opportunities for breath-based metabolic monitoring of disease.