Symposium Sessions
Day 3, June 12（Fri.） 9:45-10:15 Room B (4F 411+412)
- 3B-S1-0945
Longitudinal Immunoglobulin Glycosylation Remodeling Reflects Immune Reconstitution in Anti–IFN-γ Autoantibody–Associated Immunodeficiency
(1TMU, 2MPCGP-TMU, 3NTUH)
Chia-Ying Yang1, San-Yuan Wang2, Un-In Wu3, oI-Lin Tsai1
Anti–interferon-γ (IFN-γ) autoantibody–associated immunodeficiency is an acquired disorder characterized by neutralizing antibodies that disrupt IFN-γ signaling and impair host defense. While autoantibody titers are routinely monitored, dynamic alterations in the broader humoral immune compartment remain unclear.
We performed longitudinal immunoglobulin glycosylation profiling of 105 plasma samples from healthy controls (n = 15), drug-free remission (DF-R) patients (n = 15), and non-remission (Non-R) patients (n = 15). Samples were collected at treatment initiation (T1), 5–7 months (T2), and 12 months (T3).
In DF-R patients, total IgG galactosylation progressively increased from T1 to T3 (p < 0.001), reaching levels comparable to controls at 12 months. Subclass analysis revealed increased sialylation across IgG1, IgG2, and IgG3/4, accompanied by reduced core fucosylation, indicating restoration of anti-inflammatory glycan patterns. In contrast, Non-R patients showed only modest galactosylation changes, persistently reduced sialylation, and sustained elevation of fucosylation after 12 months, suggesting incomplete humoral normalization.
These findings demonstrate that immunoglobulin glycan remodeling reflects disease activity and remission status and may serve as a dynamic biomarker of immune reconstitution.