Poster Presentations
Day 1, June 10（Wed.） Room P (5F 501+502)
- 1P-05（1D-O2-1548）
Quantitative Analysis of Volatile Organic Compounds by High-Resolution Isobaric Discrimination Using a Preconcentrator with Gas Chromatograph Coupled to a Miniaturized Multi-turn Time-of-Flight Mass Spectrometer
(1GSS, UOsaka, 2College of Science, NTNU)
oPing Chen1,2, Yosuke Kawai1, Toshinobu Hondo1, Chia-Jung Lu2, Michisato Toyoda1
This study presents a preconcentrator-based analytical platform integrating a gas chromatograph with a miniaturized multi-turn time-of-flight mass spectrometer (Preconcentrator-GC–MULTUM) for rapid quantitative analysis of volatile organic compounds (VOCs). A multi-adsorbent preconcentrator was employed to efficiently trap and enrich VOCs with a wide volatility range prior to GC–MULTUM analysis. To increase analytical throughput, a shortened chromatographic program using a 15 m DB-624 column enabled a total analysis time of 3 minutes. Under these compressed chromatographic conditions, several VOCs exhibited partial or complete co-elution. The high mass resolving power of MULTUM enabled discrimination of overlapping isobaric ions in the mass domain, ensuring sufficient selectivity for accurate quantitation. Representative cases included the separation of the molecular ion of acetonitrile from the fragment ion of isopropanol and the resolution of overlapping fragment ions of heptane and 3-methyl-2-butanone. Quantitative analysis of 21 VOCs was achieved by combining half-cycle mode for interference-free analytes and multi-turn mode for interfered analytes. Linear calibration behavior was observed over 4–5 orders of magnitude, and detection limits reached the low-ppt to ppq range. These results demonstrate that accurate VOC quantitation can be achieved under 3-minute chromatographic conditions by combining preconcentration with high-resolution mass spectrometric discrimination.