Symposium Sessions
Day 1, June 10（Wed.） 14:20-14:40 Room B (4F 411+412)
- 1B-S1-1420
Development of High-Resolution Multi-Turn TOF-MS toward Native Mass Spectrometry
(Shimadzu Corporation)
Yusuke Tateishi, Hiroyuki Miura, Hiroko Morinaga, Yoshinori Arita, Hikaru Shibata, Qiuyi Wang, oMasaru Nishiguchi, Takeshi Fujita, Haruki Osa, Daisuke Okumura
Native mass spectrometry is a powerful solution for drug discovery and biological research. In this field, a wider mass range, higher mass resolution, and higher sensitivity are required for high-precision analysis of high-mass biomolecules, often under impurity-rich conditions. To address this challenge, a new high-resolution multi-turn time-of-flight mass spectrometer has been developed for native mass spectrometry. The instrument features a unique three-dimensional ion orbit using quasi-spherical electric sectors, which enables a flight path length of 50 m within a compact volume. A mass resolving power exceeding 200,000 has been demonstrated for high-mass proteins above 30 kDa. An overview of the instrument, ion optics, and data processing will be reported.