演題概要

ポスター発表

第3日　5月17日（水）　　P会場（ホワイエ，会議室1004-1007）

3P-30　　PDF

MALDI法における凝縮相中プロトン移動反応モデルの検討

(¹新潟薬大院・ ²新潟薬大・ ³北大・ ⁴新潟薬大院　薬剤部)
^o小林将文^1,4・ 城田起郎²・ 柘植雅士³・ 星名賢之助²

In order to quantitatively evaluate the MALDI ion signal, we examined the reproducibility of the experimental values using quantum chemical calculations under the condition that the proton transfer reaction occurs in the condensed phase of matrix molecules.　As a result, the reproducibility of the MALDI signal ratio was significantly improved compared to a previous model that assumed a gas-phase reaction. This model approach was shown to be a promising method for quantitative treatment of the MALDI signal.