日本質量分析学会 第71回質量分析総合討論会

演題概要

ポスター発表

第3日 5月17日(水)  P会場(ホワイエ,会議室1004-1007)

δサルコグリカン欠損による拡張型心筋症ハムスターの免疫代謝解析~マルチオミクス・イメージングを用いて

(1同志社生命医2島津3摂南農4京大院医5国循研6NCNP病院7北摂総合病院)
o岡邑舞子1山口真一2山本卓志2奥田晃士2井上亮3手嶋百合子4袴田圭祐4新谷祈1辻崇4雨宮妃5湊谷健司4升本英利4野口悟6西野一三6植田初江5,7池川雅哉1

Dilated cardiomyopathies (DCM) is a group of progressive, poor prognosis diseases that primarily consist of ventricular enlargement and myocardial contractile dysfunction. J2N-k hamsters (J2N-k), which have a defective δ-sarcoglycan (δ-SG) encoding gene, have been utilized as a suitable DCM animal model because the dilation of the ventricles and dysfunction was noticeable at about 20 weeks of age. Currently, the precise phenotypes of J2N-k on heart and skeletal muscles have not been elucidated. In our previous study, we have detected several cardiovascular pathological features of J2N-k heart including inflammation, fibrosis, bone formation and giant cell in the early to mid-stage of J2N-k hamsters. In order to answer what is the molecular mechanism underlying cardiac pathology of J2N-k hamsters, here we adopt and integrate multi-modal imaging mass spectrometry in terms of immunometabolism in a spatially and temporally resolved manner.