演題概要

若手研究者セッション

第3日　5月17日（水）　10:30～10:45　C会場（会議室1009）

3C-O-1030（1P-05）　　PDF

臨床N-グライコプロテオミクスによる血清膵がんマーカーの探索

(¹横市大院生命医・ ²横浜市大院医)
^o向武志¹・ 高倉大輔¹・ 大橋祥子¹・ 徳久元彦²・ 小林規俊²・ 市川靖史²・ 川崎ナナ¹

Label-free quantitative N-glycoproteomics was performed using serum from patients with advanced pancreatic cancer (PC) and healthy individuals. A total of 6,714 N-glycoforms derived from 501 proteins were identified in patients with advanced PC and healthy individual. We found that mono- or di-sialyl biantennary glycan-modified fibrinogen gamma chain (FGG) was increased in serum from advanced PC group. FGG is expected to be used as a diagnostic marker for PC (Area Under the ROC Curve = 1.0).