ポスター発表
- 第2日 5月16日（火） P会場（ホワイエ，会議室1004-1007）
-
2P-12 PDF
オルソケラトロジーレンズ装用による涙液中タンパク質の変動解析
Contact lenses are classified into soft contact lenses including hydrogel contact lens (HyCL) and silicone hydrogel contact lens (SiHyCL), and rigid gas-permeable contact lens including orthokeratology (OK) lens; OK is a method that uses specially designed gas-permeable contact lenses overnight to reshape the cornea to temporarily reduce or eliminate myopia. In this study, the effect of OK lens wear was investigated on the protein of tear fluid, using comprehensive protein analysis to evaluate their effects on ocular surface. Nine subjects between age 25 to 44 were recruited. They were classified into HyCL wearer group (n=3), SiHyCL wearer group (n=3) and control group without lens wear (n=3). All groups worn OK lenses for 2-months, and tear samples were collected at 0 day and after 2-months OK lens wearing. The proteins of tear fluid were compared on following conditions: 1) control group, HyCL wearer group and SiHyCL wearer group, 2) pre-OK wearing (baseline) and post-OK lens wearing (after 2 -months OK lens wearing). As a result, principal component analysis revealed OK lens wear alters the quantities. Moreover, statistical analysis shows OK lens wear is associated with the fluctuation in the quantity of specific groups of tear fluid proteins.