ポスター発表
- 第1日 5月15日（月） P会場（ホワイエ，会議室1004-1007）
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1P-12 PDF
MSイメージングによる植物アルカロイドであるガランタミンの分布解析
Plant alkaloids are used in various pharmaceuticals, such as anticancer drugs and analgesics. Among these plant alkaloids, galanthamine is an Amaryllidaceae-type alkaloid with acetylcholinesterase inhibitor for the treatment of neurological diseases such as Alzheimer's disease. Although the chemical synthesis of galanthamine has been successfully achieved, Narcissus is the main source of its production. Research indicates that galanthamine content varies not only with the type of Narcissus, but also with the developmental stage and the part of the plant. Pharmaceutical companies are pursuing plant species with higher galanthamine content to increase pharmaceutical productivity. Therefore, we quickly confirmed the Narcissus in our study contained galanthamine using DPiMSTM QT which is a kit for direct probe ionization unit and a quadrupole time-of-flight mass spectrometer (Q-TOF). Subsequently, we analyzed the distribution of galanthamine by MS imaging (MSI) using the iMScopeTM QT combined with Q-TOF.