演題概要

若手研究者セッション

第1日　5月15日（月）　10:45～11:00　C会場（会議室1009）

1C-O-1045（3P-29）　　PDF

ホウ素中性子捕捉療法 (BNCT) による脳腫瘍移植マウス脳の代謝影響の3D画像化

(¹同志社生命医・ ²京大原子力研・ ³島津)
^o小林奈央¹・ 近藤夏子²・ 櫻井良憲²・ 鈴木実²・ 山口真一³・ 池川雅哉¹

Here we apply an untargeted mass spectrometry-based metabolomics approach by imaging mass spectrometry in combination with UMAP method. This protocol enabled to visualize differences in broad array of metabolites in anatomical regions of the whole brain of brain tumor transplanted mice before and after boron neutron capture therapy (BNCT). This study yields important platform for metabolomics phenotyping of whole brain of brain tumor transplanted mice by defining regional homeostasis for the brain tumors to give context to the reaction to BNCT. Three-dimensional whole brain imaging will expand the possibilities for understanding the state of the brain.