ポスター発表
- 第3日 5月21日（金） P1会場（Zoom）
-
3P-08 PDF
Venomics手法によるヤエヤマサソリ毒液からの殺虫性ペプチドの同定
Scorpions utilize venom to capture prey and protect themselves from predators by showing neurotoxicity against insects and mammals. The scorpion venom contains various components, in which peptides are main components. In order to identify active components in the venom, a bioassay-guided approach is commonly used. In this experiment, the fractionation of the venom components and the evaluation of their activity is repeated until a single active component is obtained. However, the identification of active components by this method is limited to those with relatively high abundance, and the active components present only in trace amounts are often overlooked. In order to overcome this problem, a venomics approach was developed. In this method, structural information of all components is first obtained by omics analyses. Then, the activity of components is predicted based on this information, which is confirmed by synthesis of them. In this study, we identified a novel insecticidal peptide from the Liocheles australasiae scorpion venom using the venomics approach.