学会企画講演
- 第2日 5月20日（木） 15:55～16:15 A会場（Zoom）
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2A-PL-1555 PDF
走査型プローブエレクトロスプレーイオン化法の開発研究
Direct liquid extraction and ionization (DLEI) techniques incorporating electrospray ionization (ESI) have been attracting attention for the applications such as mass spectrometry imaging (MSI) and rapid analysis since the early 2000s. In order to realize the DLEI with high sensitivity, the controllability of supplying low-volume-solvent is important. Tapping-mode scanning probe ESI (t-SPESI) provide the opportunity to execute fast DLEI with charged picoliter liquid (CPL). The stabilization of probe scanning is also realized by the measurement method of probe displacement and the feedback control system in order to maintain the probe vibration amplitude on the non-flat sample surface. The advancement of research and development of t-SPESI, which utilize the physico-chemical properties of CPL, will be expected to open the door toward the applications in biomedical research in the future.