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第1日　5月19日（水）　15:10～15:30　A会場（Zoom）

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Highly-integrated Radical Induced Dissociation (HiRID)-MS/MSを用いた新規PK/RiPPハイブリッドリポペプチド脂肪酸部位の構造決定

(¹島津・ ²東大)
^o高橋秀典¹・ 寺本華奈江¹・ 岩本慎一¹・ 尾仲宏康²・ 田中耕一¹

In collision-induced dissociation (CID) -MS/MS, which is often used in structural analysis of natural products, rare gases and nitrogen molecules gas are used as collision gases. Our research group has developed a new radical-induced dissociation technique named highly-integrated radical induced dissociation (HiRID) -MS/MS using charge-neutral and highly reactive radicals instead of collision gas. In this study, we succeeded in a structural determination of novel PK/RiPP hybrid polypeptides. The use of HiRID, which integrates a variety of radical species, has made possible the structural analysis of natural products, which has not been possible before.