Abstract

Poster Presentations

Day 3, May 17（Fri.）　　Room P (Multi-purpose Hall)

3P-15　　PDF

Drug Distribution in Whole-Body Tissue Sections by Imaging Mass Spectrometry

(¹Asahi Kasei Pharma, ²Asahi Kasei)
^oRika Komatsu^1,2, Toyohiko Yamamoto², Terumi Sakabe², Kiyoshi Ogawa¹

Imaging mass spectrometry (IMS) can reveal the distribution of drugs and their metabolites on tissue sections. Therefore, it is useful for elucidation of mechanisms of pharmacokinetics, efficacy and toxicity. Although, the IMS technology has evolved remarkably, there are many problems to use of drug discovery research. Particularly, it is difficult to apply to whole-body tissue sections and acquire distribution of compounds that are low sensitivity in tissues. In this study, we attempted acquisition of celecoxib distribution in mouse whole-body tissue sections.