Abstract

Table of contents

Oral Sessions

Day 3, May 17（Fri.）　14:45-15:05　Room E (201)

3E-O2-1445　　PDF

Visualization of Metabolomic Status of Murine Thymus with Imaging Mass Microscope

(¹Doshisha Univ., ²Shimadzu, ³Kansai Med. Univ.)
^oYudai Tsuji¹, Takushi Yamamoto², Shinichi Yamaguchi², Hideshi Fujiwake², Tomoyuki Nakamura³, Masaya Ikegawa¹

The lymphatic system consists of lymphatic organs, a conducting network of lymphatic vessels, and the circulating lymph. The primary or central lymphoid tissues generate lymphocytes from immature progenitor cells. The thymus and the bone marrow constitute the primary lymphoid organs involved in the production and early clonal selection of lymphocyte tissues. Here we have analyzed immune systems in terms of metabolites using Imaging Mass Microscope, a matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS). In this study, we tried to visualize distribution of metabolites from a whole mount section of adult mouse with MALDI-QIT TOF MS empowered with software that enables data mining and quantification of ions which discriminate different biological states.