日本質量分析学会 第67回質量分析総合討論会

Abstract

Oral Sessions

Day 3, May 17(Fri.) 16:25-16:45 Room B (102)

Mass Spectrometry Imaging for Drug Distribution Using 3D Model Tissue

(1Osaka Univ., 2Osaka Univ., 3Osaka Univ.)
oShuichi Shimma1, Michiya Matsusaki1, Yoichi Otsuka2, Masamitsu Konno3

Conventional mass spectrometric analysis using tissue extraction precludes determining information on their spatial distribution. On the other hand, mass spectrometry imaging (MSI) is a feasible technique to visualize drugs, metabolites, and so on. However, there are a lot of challenges to perform MSI in animal and human tissues due to ethical problem. Especially, EU and other countries have banned testing cosmetics on animals. Recently, MSI using three-dimensional (3D) model tissue to evaluate drug delivery/efficacy is one of the attractive applications as alternative specimens. Based on this background, research group including mass spectrometrist, chemist, and basic biologist has been established in Osaka University (Fig. 1). This approach is still novel, therefore in this presentation, I would like to present literature based current status of MSI using model tissue (especially, CTOSs: cancer tissue-originated spheroids).