Oral Sessions (Day1, Day2, Day3)
Poster Presentations
(Day1, Day2, Day3)
Poster Presentations
- Day 2, May 16(Thu.) Room P (Multi-purpose Hall)
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2P-33 PDF
Quantitative Comparison of Amines in WKY and SHRSP Rat Brain Using MALDI ImagingMS "Triple Spray" Method
MALDI-Imaging Mass Spectrometry can visually elucidate the distribution of substances in biological sample. In case of using this technique for application in drug development, it requires quantitativity. However, currently there is no effective quantitative method. In order to solve this problems, we developed the Triple Spray method using derivatization reagent mTRAQ. This method enables us to quantify the amine distribution by normalizing the amine specific matrix effect. This allows us to get a better representation of the distribution and quantitate each target compound. In this study, we compared the distribution of neurotransmitter amino acids in WKY rat brain and SHRSP rat brain quantitatively.