オーラルセッション
- 第4日 5月18日（金） 12:40～13:00 A会場（オービットホール）
-
4A-L-P-1240 PDF
Development of salivary protein biomarkers for oral cancer
Oral squamous cell carcinoma (OSCC) represents a serious and growing problem in many parts of the globe, including Taiwan. Most cases of OSCC develop from visible oral potentially malignant disorders (OPMDs), which exhibit heterogeneous subtypes with different transforming potentials. Such complexity and uncertainty complicate the early detection of OSCC during routine visual oral cancer screenings. Thus, we urgently need new approaches that will enable the early detection of OSCC, such as the development of saliva protein biomarkers. Although >1400 published studies have searched for biomarkers for head/neck cancers, including OSCC, few reported biomarkers have moved into clinical practice. To address this important clinical issue, our team has applied MRM-MS-based approaches to verify dozens of potential protein biomarkers in ~500 saliva samples from OSCC patients and controls enrolled in the Taiwan's Oral Cancer Screening Program (PNAS USA. 113:11549-11554, 2016). In this seminar, further studies including the verification of new biomarkers by immuno-MRM-MS, the assessment of intra-day and inter-day variability of salivary proteins in samples from healthy donors, as well as the development of point-of-care test for selected biomarker will be presented and discussed.