プログラム

ポスター発表

第3日　5月17日（木）　　ポスター会場

3P-48　　PDF

ピリリウム系誘導体化試薬による脳内カテコールアミンの可視化

(¹福島大・ ²大陽日酸・ ³慶応大（医）)
^o平修¹・ 池田明夏里²・ 杉浦悠毅³

In this time, we investigates the localization of catechol amines such as L-DOPA, dopamine(DA), 3-MT in which engage physiological change of mice brain. Py-I can selectively and efficiently react with the primary amino group which has more than two carbon chain by the reaction of pyrylium salts with nucleophiles under alkaline conditions, thereby increasing the mass by 105.1. Py-I-labeled L-DOPA and DA showed m/z 302.2 and 258.1 increasing the mass by 105.1 from original mass, respectively. MSI showed the change of localization of target molecules. Interestingly, L-DOPA and DA localized at brain stem and ventral striatum.