日本質量分析学会 第66回質量分析総合討論会

プログラム

ポスター発表

第3日 5月17日(木)  ポスター会場

High resolution trapped ion mobility mass spectrometry analysis of isomeric compounds

(1ブルカージャパン2ブルカーダルトニクス)
o森美詞1Meyer, Sven2Sander, Peter2Michalski, Annette2Suckau, Detlev2

Ion mobility (IM) separation hyphenated with high resolution accurate MS extends substance identification and characterization capabilities to a new dimension. IM permits to separate isobaric or isomeric compounds. We applied Trapped Ion Mobility Separation (TIMS) on the new timsTOFTM instrument(Fig.1). Model compounds were isomeric trisaccharides or lipids. In real-world samples these compounds are difficult to identify using LC-MS-only methods as these don´t provide clean MS/MS spectra. Using the timsTOF with its ion mobility expansion technology (imeXTM) facilitated method development for an appropriate IMS separation.