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第3日　5月17日（木）　09:00～09:15　B会場（星雲1）

3B-O1-M-0900　　PDF

北アフリカ棲息種サソリ Buthacus leptochelysの毒液に含まれる新規殺虫性ペプチドの構造決定

(¹京大院農・ ²アル=アズハル大)
^o義本裕介¹・ Mohammed, Abdel-wahab²・ Moustafa, Sarhan²・ 宮下正弘¹・ 中川好秋¹・ 宮川恒¹

Scorpion venom contains various bioactive peptides that show insecticidal, antimicrobial or hemolytic activity. In this study, we isolated a new insecticidal peptide, Bl-1, from the venom of the north African scorpion Buthacus lteptochelys by bioassay-guided RP-HPLC fractionation. Primary structure of Bl-1 was determined by Edman degradation and de novo sequencing analysis. As a result of sequence database search, Bl-1 shares sequence similarity to scorpion α-like toxins, which act on Na+ channels.