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ポスター発表

第2日　5月16日（水）　　ポスター会場

2P-32　　PDF

MALDIイメージングによるNASHモデル肝臓組織の繊維化部位における胆汁酸および脂質類のプロファイル

(¹島津・ ²九大レドックスナビ・ ³田辺三菱製薬)
^o山崎雄三¹・ 山口真一¹・ 押川倫憲¹・ 三浦大典²・ 山崎真³

Non-alcoholic steatohepatitis (NASH) is an advanced form of Non-alcoholic fatty liver disease (NAFLD), and is recognized to often progress to cirrhosis and hepatocellular carcinoma. A liver excised from an animal model raised to forcibly express NASH is quite useful to study the disease, because pathological findings of the organ are similar to the one from human patients. Whereas some metabolomics methods using LC- or GC-MS have been applied to the analysis of the organ, visualization of metabolites on pathological section is necessary to discuss disease states with relevance to various staining. We will present a metabolic profile of biochemical compounds in some pathological states, which is possibly related to a dynamics of the fibrosis in liver, by using MALDI imaging.