日本質量分析学会 第66回質量分析総合討論会

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ポスター発表

第2日 5月16日(水)  ポスター会場

オキサリプラチン誘導性肝障害ブタモデルにおける肝臓LA-ICP MSイメージング

(1京大病院2京大院薬3サーモフィッシャー4同志社大生命医)
o戸田怜1井口公太1中村直彦1瀬尾智1中川貴之2黒木康夫3池川雅哉4上本伸二1

Oxaliplatin (L-OHP) is a platinum (Pt) anticancer agent and is one of the effective drugs for the treatment of advanced colorectal cancer. However, it may cause liver injury, including sinusoidal obstruction syndrome (SOS), which would be associated with increased rates of morbidity after liver surgery in patients with colorectal liver metastases. Unfortunately, the mechanism of SOS is not clearly understood. In this study, we succeeded in establishing the pig model of SOS using L-OHP-based chemotherapy. Furthermore, laser ablation ICP mass spectrometry (LA-ICP MS) allowed us to visualize the characteristic distribution of Pt on the pig liver tissues with quantitative information. Combined with the pathological findings on HE stainings and blood Pt concentrations, our findings would give a clue to better understanding of the mechanism of SOS.