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ポスター発表

第2日　5月16日（水）　　ポスター会場

2P-23　　PDF

放線菌培養物のESI-MS/MSスペクトルを指標にした化合物群のプロファイリング

(¹微化研・ ²海洋機構)
^o高橋裕子¹・ 波多野和樹¹・ 五十嵐雅之¹・ 澤竜一¹・ 加藤千明²

Secondary metabolites derived from microbes are quite diverse. Approximately 40% of biologically active compounds derived from microorganisms have been produced by actinomycetes and many useful substances, including pharmaceuticals are found in actinomycete products. Mass spectrometry has played an important role in the discovery of novel bioactive compounds. We have performed targeted or nontargeted analyses of extracts of actinomycete broth by LC-ESI-MS analyses based on exact mass and retention time. There is a problem that many unidentified compounds are listed in the analyses. In this study, we report that the compounds were profiled by principal component analysis of the MS/MS spectra of actinomycete broth extract, focusing on the phenomenon that compound having MS/MS spectra of similar patterns contain similar partial structures.