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1A-O2-M-1740 PDF
質量分析を用いた一次代謝アダプテーション機構の再検討
The central carbon metabolism is an old frontier of biology that should be revisited with trans-omics data obtained by mass spectrometry. 13C-Metabolic flux analysis (13C-MFA) of paclitaxel treated breast cancer cell line (MCF-7) showed that the metabolic flux levels of the tricarboxylic acid cycle and anaerobic glycolysis were significantly increased and decreased by a low-dose treatment of paclitaxel, respectively. A gap between the total regeneration and consumption rates of ATP in the paclitaxel-treated cells was 1.2 times greater than that in the control, suggesting that ATP demand was significantly increased by the paclitaxel treatment, probably due to the activation of microtubule polymerization.