3P-07 PDF
Multi-Mode (DESI & MALDI) Mass Spectrometry Imaging in Clinical Research
Recently, desorption electrospray ionization (DESI) has been developed and provides an alternative ambient pressure technique to ionize clinically important molecules directly from tissue. DESI, a surface analysis technique incorporating an electrospray probe, can be utilized as a spatially resolved imaging technique by rastering a surface under the spray using a high precision XY stage. No modification to the sample such as matrix addition is necessary and therefore minimum sample preparation is required for a DESI imaging experiment, making this technique more compatible within a clinical research environment. Here we compare and contrast MALDI and DESI imaging techniques on a Q-TOF mass spectrometer.