Abstract

Table of contents

Plenary Lectures: Award Lecture
Oral Sessions Day1, Day2, Day3: Poster Presentations Day1, Day2, Day3
Workshops: Panel Discussion
Luncheon Seminar Day1, Day2, Day3: Timetable

Poster Presentations

Day 2: Thursday, May 19　　Poster Room（Gekko）

2P-23　　PDF

Linkage-Specific Sialic Acid Analyses of Plasma N-Glycans in Japanese Semisuper Centenarians

(¹TMIG, ²Shimadzu, ³Keio Univ.)
^oHiroki Tsumoto¹, Takashi Nishikaze², Yuri Miura¹, Yukiko Abe³, Yasumichi Arai³, Shinichi Iwamoto², Nobuyoshi Hirose³, Koichi Tanaka², Tamao Endo¹

We developed a method for a linkage-specific sialic acid analysis of human plasma N-glycans by a combination of MALDI-TOF MS and sialic acid linkage-specific alkylamidation (SALSA). Using this method, over 100 N-glycans containing multi-branched and highly sialylated were observed in human plasma, and the ratios of α2,3-linked to α2,6-linked sialic acid in two-branched glycans containing fucose were increased in semisuper centenarians compared with those in aged controls.