Abstract

Table of contents

Plenary Lectures: Award Lecture
Special Programs: Oral Sessions Day1, Day2, Day3
Poster Presentations Day1, Day2, Day3: Luncheon Seminar Day1, Day2, Day3
Timetable

Oral Sessions

Day 3: Friday, June 19　9:10-9:30　Room C（101）

3C-O1-0910　　PDF

Detection of accumulated glutathione hydropersulfide on human colon cancer-bearing livers of superimmunodeficient NOG mice by MALDI MS imaging

(¹Keio Univ., ²JST•ERATO, ³Shimadzu)
^oAkiko Kubo¹, Mitsuyo Ohmura^1,2, Tsuyoshi Nakanishi³, Takako Hishiki¹, Takehiro Yamamoto^1,2, Makoto Suematsu¹

Glutathione hydropersulfide (GSSH) is a highly reactive nucleophile, and easily converted into Glutathione-S-sulfonate (GSSO₃H) through atmospheric MALDI ionization. By detecting GSSO₃^- in atmospheric pressure MALDI imaging mass spectrometry, we revealed the accumulation of GSSH in human colon cancer region of tumor-metastasizing liver of superimmunodeficient NOG mice.