1P-41 PDF
Supercritical fluid chromatography/triple-quadrupole mass spectrometry-based method for highly sensitive and high-throughput analysis of multiresidue pesticides
Recently, a generally applicable screening method for multiresidue pesticide analysis, which is simple, quick, accurate, and has a reliable performance, is becoming increasingly important for food safety and international trade. Herein, we established a high-throughput screening methodology that enables the detection of multiresidue pesticides using supercritical fluid chromatography coupled to a fast-scanning triple-quadrupole mass spectrometry (SFC/MS/MS). A total of 509 chemicals covering a wide polarity range (logPow from ‒4.6 to 8.1) and a wide molecular range (from 99.0 to 1052.0) were analyzed simultaneously through a combination of fast-speed multiple reaction monitoring (MRM) with positive/negative polarity switching and highly efficient separation by SFC. The developed analytical system is a potentially useful tool for practical multiresidue pesticide screening with high-sensitivity and -throughput.