2P-18 PDF
Development of DESIRT (Desalination in Real Time) technology for LC/MS
Non-volatile buffers in RPLC are useful to obtain good separation of complex mixtures, it is well known, however, that the non-volatile buffers cannot be used for LC/MS. The following problems cause by using non-volatile buffers.
1. Co-existing non-volatile salts suppress the ionization of analytes.
2. Non-volatile salts cause the clogging the capillary and the serious contaminations.
Even if what "non-volatile buffer cannot use fundamentally" becomes the common sense of LC/MS, in addition in LC/MS, use of non-volatile buffer is desired. So we have developed the desalination interface that could continuously remove the non-volatile salts from mobile phase by using the micro-fluidic technology and magnetic TiO2 particles.