2A-O1-1020 PDF
Standardized Sample Preparation in Imaging Mass Spectrometry for Drug Detection
Methodological standardization in imaging mass spectrometry (IMS) is one of the active subjects in IMS studies. We visualize the drug distributions in a large number of tissues obtained from cancer patients. In order to visualize the drug delivery in each patient with high accuracy, we have to measure all specimens under the same conditions. In this viewpoint, the standardized procedure from sample preparations including high sensitive matrix application to image analysis is essential. In this presentation, we introduce the standardized procedure including two-step matrix application and discuss its effectiveness.