オーラルセッション
- 第3日 5月13日（水） 15:50～16:10 A会場（特別会議場)
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3A-O13-1550 PDF
ノンターゲット解析を用いたグラム陰性腸内細菌のLipid Aの構造推定
A method for the analysis of lipid A, an important immune activator of gram-negative bacteria, was developed by using LC-QTOF-MS. The sharp peak of lipid A was observed by employing a metal-free column and high pH basic solvent. MS/MS spectra assignment enabled the structure estimation of lipid A. This method was successfully applied to the analysis of in vitro cultured gram-negative gut bacteria strains. The results suggest the structural diversity of lipid A.