演題概要

オーラルセッション

第2日　5月12日（火）　9:05～9:25　A会場（特別会議場)

2A-O4-0905　　PDF

ホットメルトレーザーマイクロダイセクションおよび並列LCを用いた高速LC-MSイメージングシステムの開発

(¹島津基盤研・ ²名大環研)
^o古賀裕介¹・ 洪暎淳¹・ 松本龍太¹・ 鈴木弘美²・ 小野健治²・ 前田裕樹¹・ 小河潔¹・ 澤田誠²

Mass spectrometry imaging(MSI) is a powerful tool for visualize spatial distribution of molecules. Although MALDI-MSI is widely used in pharmacokinetics, metabolite analysis, biomarker search, it has several disadvantages in high sensitivity analysis or quantitative analysis. On the other hand, LC-MS is a great tool for high sensitivity quantitative analysis of molecules. However, LC-MS imaging is difficult in terms of sample preparation and throughput. In this study, we have developed high throughput LC-MS imaging system using thermal film-based laser microdissection and parallel LC.