Abstract

Poster Presentations

Day 1, May 15（Wed.）　　Room P (Multi-purpose Hall)

1P-39　　PDF

Clarify of Cancer Drug Resistance Mechanism by Metabolic Profile Time Resolved Analysis

(Osaka Univ.)
^oMasaharu Maruyama, Chie Araki, Nobuyuki Okahashi, Fumio Matsuda

A metabolic response of the human breast cancer cell line (MCF-7) against a υtreatment of paclitaxcel, an antimitotic agent, was investigated by the metabolic profiling analysis using GC-MS. The results showed that the levels pyruvate and phosphoenolpyruvate decreased and increased at 3 h, respectively, suggesting an inhibition of pyruvate kinase after the paclitaxcel treatment.