日本質量分析学会 第67回質量分析総合討論会

Abstract

Oral Sessions

Day 1, May 15(Wed.) 18:20-18:40 Room D (202)

SICRIT: A New Sensitive and Versatile Ion Source for Both, Screening and Quantitation

(1Plasmion, 2CTC, 3ETH Zurich)
oJan-Christoph Wolf1, Anna Huba2,3, Mario Mirabelli2,3, Renato Zenobi2,3

Soft Ionization by Chemical Reaction In Transfer (SICRIT) is a flow-through ionization source for LC-MS systems. SICRIT directly merges the atmospheric pressure inlet of the MS with a small dielectric barrier discharge based ionization (DBDI) source. This significantly enhances ion transmission into the MS and thereby the sensitivity. The ionization process is very soft usually yielding solely MH+ analyte species. As a further advantage, the source does not need any additional gas or liquid supplies and can be attached to virtually any atmospheric pressure inlet MS. Due to its flow-through design, it can be used for direct analysis without any sample pretreatment or in combination with e.g. LC, GC, SPME or laser ablation.
Several studies were conducted on various instruments and directly coupled to chromatographic analysis systems, e.g. a nano-LC, a GC, and a laser ablation system. The source has proven to be capable of efficiently ionizing a wide range of substance classes including chemical warfare agents, PAH, pesticides, and illicit drugs with general sensitivities found to be in the low ppt range.
Our results show that the SICRIT ionization source is very sensitive and versatile for screening or in-field-applications as well as for interfacing to any chromatography or sample delivery system.