Oral Sessions
（Day1, Day2, Day3, Day4）
Poster Presentations
（Day1, Day2, Day3, Day4）
Luncheon Seminars
（Day1, Day2, Day3, Day4）
Poster Presentations
- Day 4, May 18（Fri.） Poster
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4P-17 PDF
Proteomic Analysis of Kidney Biopsy Tissues from Chronic Kidney Disease Patients
Chronic Kidney Disease (CKD) is a serious disease, which progresses to the end-stage chronic renal failure and patients with CKD may be treated with dialysis therapy or kidney transplantation. By pathology, CKD is classified into several diseases, such as diabetic nephropathy, IgA nephropathy, nephrosclerosis and others. To understand molecular mechanisms of the progression of CKD, especially in the glomerulus as the major injury site is the glomerulus, glomerular sections were microdissected from formalin-fixed paraffin-embedded (FFPE) kidney biopsy tissues of patients with CKD or normal kidney tissues which were removed for cancer treatment and analyzed by a label-free LC-MS quantitation (modified normalized spectral index, SIN). Proteins identified in the glomerulus uniquely in each disease or with more than 2-fold SIN value were analyzed by DAVID pathway analysis. Several unique pathways were elucidated in each CKD disease by the analysis, which may promote development of new radical therapies in the near future.