Program

Oral Sessions

Day 3, May 17（Thu.）　09:00-09:15　Room B (Seiun 1)

3B-O1-M-0900　　PDF

Structural Characterization of a New Insecticidal Peptide from the Venom of the North African Scorpion, Buthacus leptochelys

(¹Kyoto Univ., ²Al-Azhar Univ.)
^oYusuke Yoshimoto¹, Abdel-wahab Mohammed², Sarhan Moustafa², Masahiro Miyashita¹, Yoshiaki Nakagawa¹, Hisashi Miyagawa¹

Scorpion venom contains various bioactive peptides that show insecticidal, antimicrobial or hemolytic activity. In this study, we isolated a new insecticidal peptide, Bl-1, from the venom of the north African scorpion Buthacus lteptochelys by bioassay-guided RP-HPLC fractionation. Primary structure of Bl-1 was determined by Edman degradation and de novo sequencing analysis. As a result of sequence database search, Bl-1 shares sequence similarity to scorpion α-like toxins, which act on Na+ channels.