Oral Sessions
(Day1, Day2, Day3, Day4)
Poster Presentations
(Day1, Day2, Day3, Day4)
Luncheon Seminars
(Day1, Day2, Day3, Day4)
Poster Presentations
- Day 2, May 16(Wed.) Poster
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2P-32 PDF
Metabolic profile of bile acids and lipids in fibrosis of NASH-model liver using MALDI Imaging at 20 μm spatial resolution
Non-alcoholic steatohepatitis (NASH) is an advanced form of Non-alcoholic fatty liver disease (NAFLD), and is recognized to often progress to cirrhosis and hepatocellular carcinoma. A liver excised from an animal model raised to forcibly express NASH is quite useful to study the disease, because pathological findings of the organ are similar to the one from human patients. Whereas some metabolomics methods using LC- or GC-MS have been applied to the analysis of the organ, visualization of metabolites on pathological section is necessary to discuss disease states with relevance to various staining. We will present a metabolic profile of biochemical compounds in some pathological states, which is possibly related to a dynamics of the fibrosis in liver, by using MALDI imaging.