Program

Poster Presentations

Day 2, May 16（Wed.）　　Poster

2P-31　　PDF

MALDI Imaging Mass Spectrometry for the pathological study of cardiac amyloidosis biopsies

(¹Bruker Japan, ²Doshisha Univ., ³Georges-Pombidou European Hospital, ⁴NCVC)
^oTakashi Nirasawa¹, Megumi Terada², Yuki Kuzuhara², Yume Mukasa², Hiroko Namba², Nobuto Kakuda², Patrick Bruneval³, Hatsue Ueda⁴, Masaya Ikegawa²

Endomyocardial biopsy (EMB) is performed on a regular basis for the diagnosis of cardiac diseases such as cardiac allograft rejection (CAR), cardiomyositis, dilated cardiomyopathy and cardiac amyloidosis.
Here, we adopt MALDI-imaging mass spectrometry (MALDI-IMS) on EMB tissues to obtain a comprehensive protein mapping. For this purpose, we developed a novel protocol with ultra-high speed mass spectrometry that bears advantages in its rapidity, sensitivity, and reproducibility.