Program

Oral Sessions

Day 2, May 16（Wed.）　11:25-11:45　Room B (Seiun 1)

2B-O1-P-1125　　PDF

System level understanding of host-specific immune dynamics in Fusarium wilt in plant

(NIPGR)
Eman Elagamey, Kanika Narula, Sudip Ghosh, Arunima Sinha, Pooja Aggarwal, Niranjan Chakraborty, ^oSubhra Chakraborty

Morbidity and mortality associated with fungal infections and emergence of resistant fungal strains necessitate study of fungal pathogenesis and host innate immunity. Innate immune response is governed by genotype-dependent conserved cellular events. However, the underlying molecular mechanism by which this process is regulated against fungal pathogen is less explored. Fusarium oxysporum, an agronomically important pathogen is known to be associated with vascular wilt in plant. Wilt disease is a major impediment for global chickpea productivity. To elucidate regulatory framework of Fusarium-associated disease and immune response, we analyzed the gene and protein expression during infection, integrated temporal expressions and network analysis in chickpea. Temporal proteome and metabolome was developed with ECM enriched fraction. Longitudinal spatiotemporal multiomics analyses and the derived biomolecular networks revealed organ and organelle function in contrasting genotypes during fungal invasion. Network analysis identified major protein hubs enriched in known and novel disease- and immunity-related prognostic proteins pointing towards the onset and context of disease signaling and metabolic pathway activations. Finally, this study for the first time provides novel insights on host-specific immune signaling that impinge upon the surveillance mechanism of innate immunity in Fusarium-associated disease.