演題概要

ポスター発表

第2日　5月18日（木）　　P会場（多目的ホール）

2P-31　　PDF

GC/MSイオン源のマトリクス効果の低減と疾患メタボロミクス用精度管理法の開発

(¹阪大院工・ ²阪大院医・ ³AMED-CREST)
^o古野正浩¹・ 宿里ひとみ¹・ 斎藤裕美¹・ 大森一生²・ 山本裕一²・ 片上直人²・ 下村伊一郎²・ 福崎英一郎^1,3

GC/MS is widely used as a useful tool for metabolomics. However in the disease metabolomics studies targeting plasma, the variation of measurement data is too large for analyzing the cohort samples due to the matrix effect in the ion source. Here we optimized the extraction, deproteinizing and cleanup steps in the sample preparation method, monitored the state of the ion source, and applied it to continuous measurement of about 230 samples.