1P-15 PDF
有機マトリックスを共存させた金属薄膜表面支援レーザー脱離イオン化イメージング質量分析法によるマウス肝ホモジネート切片中のオランザピンの検出
The matrix-enhanced surface-assisted laser desorption/ionization method (ME-SALDI) was applied to the mass imaging of section samples of mouse liver homogenates with olanzapine. Use of zirconium (Zr) as a sputtering metal with this method was effective for the detection of olanzapine. Sample pretreatment with water for MALDI markedly enhanced olanzapine detection. In contrast, the same pretreatment was less effective for ME-Zr-SALDI.