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第1日　5月17日（水）　　P会場（多目的ホール）

1P-11　　PDF

２型糖尿病モデルラット腎臓のプロテオミック・イメージング解析

(¹同志社大生命医・ ²ブルカーダルトニクス・ ³小野薬品工業株式会社)
^o森下宜彦²・ 葛原由貴¹・ 平田千慧¹・ 韮澤崇²・ 工藤寿治²・ 益山慶^1,3・ 角田伸人¹・ 池川雅哉¹

Diabetic nephropathy is the most common cause of end stage renal failure. The development of an experimental animal model with diabetic nephropathy that closely mirrors human disease will significantly enhance our understanding of the nephropathy and accelerate our progress toward more effective treatments. A new inbred rat strain, Spontaneously Diabetic Torii (SDT) rats are excellent animal models to apply for this type of study. In this investigation, we demonstrate a comprehensive matrix-assisted laser desorption/ionization (MALDI) mass imaging mass spectrometry (IMS) approach to study the molecular distribution of proteins in diabetic kidney from SDT. Especially, we focus on the minimal changes of diabetic kidney at early stages of the disease progression.