演題概要

オーラルセッション

第1日 5月17日(水) 14:45~15:05 B会場(102)

質量分析技術の臨床的社会実装に向けて ―課題と将来性―

(1千葉大病院2サーモフィッシャー)
o野村文夫1窪田雅之2

Short Abstract: Mass spectrometry (MS) has undergone rapid technical development and its clinical applications are growing. Tandem mass spectrometry for newborn screening is now available nationwide in Japan. Also, LC-MS/MS is an effective tool in therapeutic drug monitoring and toxicology. More recently, bacterial identification using MALDI-TOF MS has been introduced into the real world medicine, making a revolutionary shift in clinical diagnostic microbiology. Although LC-MS/MS has a number of advantages over traditional immunoassays including enhanced specificity, ability to simultaneously measure multiple analytes at a time, MS applications in clinical chemistry laboratories, however, has remained very limited because of substantial challenges. These challenges include the high capital cost of equipment, requirements for a skilled labor force, lack of standardization and automation, and regulatory
uncertainty ( PMDA clearance of MS as an established detector and reimbursement issues)